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Objective: To study the expression of small ubiquitin-like modifier 1 SUMO-1 in aseptic loosening of prosthesis implants and to investigate its role in regulating the susceptibility of prosthesis-loosening fibroblast-like synoviocytes FLS to Fas-induced apoptosis. Methods: Specimens of aseptically loosened tissue were obtained at revision surgery, and the expression of SUMO-1 was analyzed by in situ hybridization. Immunohistochemistry and confocal microscopy were used to study the subcellular localization of SUMO Results: SUMO-1 was expressed strongly in aseptically loosened tissue and was found prominently at sites adjacent to bone. Knockdown of SUMO-1 had no effect on spontaneous apoptosis but significantly increased the susceptibility of prosthesis-loosening FLS to Fas-induced apoptosis. Modification of nuclear proteins by SUMO-1 contributes to the antiapoptotic effects of SUMO-1 in prosthesis-loosening FLS, providing evidence for the specific activation of sumoylation during their differentiation.
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Gay Munich Guide - Gay Saunas and Bathhouses - Patroc

Manu fled Egypt a little bit at a time. First, he flew to Cyprus, because he knew a travel agent who helped him get a visa. Manu spent a few days in Larnaca, and he got a tattoo in Nicosia, and then he returned to Cairo. The next stop was Saudi Arabia. It may have been the first time in history that a gay man was going to Mecca as part of a plan to escape a Muslim country, but Manu wanted his passport stamped.
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Since then almost 50 years passed but gay, lesbian, and queer people still suffer from Homophobia all over the world. We would like to wish Happy Pride ! Although Bavaria is supposed to be one of the more conservative German states, a total amount of seven CSD festivals are taking place from June to August as you can see in our Gay Pride Calendar Germany for Bavaria is the largest state in south-eastern Germany with borders to Czechia and Austria and several German states.
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But no marriage-like relationship is blessed with this, he said in an interview with Stern on Monday. Marriage is also not possible. At that time, Marx said the issue was not a priority for the German episcopate.
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